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The tool followed the decision tree in Supplementary Fig
In certain circumstances, clinicians may combine therapies that target different pathways
Starting vitamin B12 treatment without appropriate assessment can make later test results harder to interpret and may delay investigation of another condition
The colder the better
Nonetheless, this work has identified novel findings that support future studies to determine whether microbiome changes are contingent upon the combination of both NNMTi and LD switch and mediated through direct NNMTi-driven mechanisms or through indirect mechanisms such as weight or fat loss 8,13
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