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What are the ethical considerations in prescribing GLP-1 agonists to women of childbearing potential, given the risks to fetal development and the necessity of contraception

Dalton TP, Dieter MZ, Yang Y, Shertzer HG, Nebert DW (2000) Knockout of the mouse glutamate cysteine ligase catalytic subunit (Gclc) gene: embryonic lethal when homozygous, and proposed model for moderate glutathione deficiency when heterozygous

Seek medical attention if you experience extreme thirst with massive urine output (possible diabetic emergency), dark urine despite adequate fluid intake, pain or burning during urination, blood in urine, sudden decrease in urine output, or if increased urination persists beyond 12 weeks without improvement

OASIS-4 Trial OASIS-4 was a randomized, double-blind, placebo-controlled phase 3 trial of 71 weeks with co-primary analysis at week 64

there is no documented protocol for intermediate values like 3.75 mg or 11 mg, and there is nothing documented above 15 mg