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Potential Adverse Effects The FDA flagged concerns about: Immunogenicity and antibody formation with repeated dosing Peptide-related impurities from compounding pharmacy manufacturing Unknown effects on cardiovascular, hepatic, and renal function with chronic use Theoretical acceleration of undetected tumor growth Current Research Gaps The literature reveals critical knowledge deficits preventing definitive cancer risk conclusions: Long-term human safety: No prospective study has followed BPC-157 users for months or years to document cancer incidence or tumor progression

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Oral supplements are more accessible to incorporate and more convenient than topical applications