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Although GLP-1 receptor agonists (GLP-1RAs) were initially developed for the management of diabetes and weight loss, their therapeutic applications have since broadened considerably to encompass a range of cardiovascular, renal, and metabolic disorders [15,16,17]
A 2022 literature review concluded there is no clear evidence of increased thyroid cancer (MTC or other types) with GLP-1 RA use in humans ( [122] ) ( [149] )
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In the SURMOUNT-1 trial, Mounjaro produced up to 22.5% body weight loss at 72 weeks, compared to roughly 3% with Victoza in the LEADER trial
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