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Several reasons may explain the observation that the mean treatment difference was 12.5% in STEP 1 and 8.7% in SELECT
This pharmacokinetic limitation was a key factor in choosing SC injections for the FDA-approved product (Vyleesi)
Therapeutics and clinical risk management
The post states plainly that no clinical trial demonstrates direct GLP-1 elevation from yerba mate in human subjects, and that the drink does not raise GLP-1 in meaningful clinical amounts
There are also important warnings and contraindications (for example, certain thyroid tumor history), and Wegovy isnt appropriate for everyone
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