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Further investigations using immunohistochemical labeling revealed apparent interactions between spadin and the selective serotonin agonist RS 67333's actions on Zif268 expression in the dorsal raph nucleus (DRN), indicating both additive and synergistic actions
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The same disparity between rich animal data and sparse human trials characterizes many peptide compounds, partly because the economics of pharmaceutical development disfavor compounds that cannot be patented in their natural form
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