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The effect of rosiglitazone on cellular growth was associated with cell cycle arrest and with an increase of cyclin-dependent kinase inhibitors p21 (cip1) and cyclin-dependent kinase regulator p27 (kip1), a decrease of cyclin D1, and inactivation of Rb protein

Cardiopulmonary bypass (CPB) is related to multiple effects that may contribute to post-operative myocardial injury and cardiac dysfunction, including ischemiareperfusion injury after removal of the aortic clamp, the subsequent generation of reactive oxygen species, and increased production of inflammatory mediators [2, 3]

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