does semaglutide go out of date Can I Use After Expiration Date? Safety and Risks Is It Safe to Use

Some weeks show no loss despite perfect adherence

10.1038/s41598-019-45535-y 109 MeenaM.Van DelenM.De LaereM.SterkensA.Costas RomeroC.BernemanZ.et al

Recurrent abdominal pain or cramps typically related to defecation and associated with change in stool frequency or appearance Changes in stool could include constipation (in constipation-predominant IBS [IBS-C]) or diarrhea (in diarrhea-predominant IBS [IBS-D]) Other symptoms not directly associated with the gastrointestinal tract may include headaches, backaches, lethargy, and anxiety or depression What are the Risk Factors for IBS

(PubMed) Callaghan BC, Little AA, Feldman EL, Hughes RA

50,51 Impaired FGF21 responses are associated with exaggerated postprandial inflammation, suggesting that endogenous FGF21 normally acts as a brake on inflammatory activation during nutrient excess