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In research models with elevated NNMT activity, this methylation reaction has been reported to deplete cellular SAM pools and reduce NAD+ availability

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10.1038/s41401-020-0478-3 64 LiangX.HuC.HanM.LiuC.SunX.YuK.et al (2022)

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Agents such as quercetin, jujuboside A, cornuside, boeravinone C, cycloastragenol, and the JinChan YiShen TongLuo formula have been demonstrated to block TECs apoptosis through modulating mitochondrial function, ER stress, or key signaling pathways (117, 120, 128131), exhibiting promising translational potential

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Chemical research in toxicology 25 , 94100, doi: 10.1021/tx200242a (2012)

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