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1994, 266: R979-R988
Within this framework: HRT supports neural bioenergetics and mitochondrial stability, helping sustain adequate energy supply GLP-1 therapies reduce systemic and central inflammatory stress, improving the environment in which neurons function Rather than acting in isolation, these therapies may operate synergistically to stabilize both energy production and stress response systems within the brain
Nat Med 18:18451856
Zepbound's profile includes similar GI effects plus additional reports of gastroesophageal reflux disease (GERD), eructation (belching), and dyspepsia
Nonetheless, GLP-1RA is known to affect the intestinal environment and, indeed, changes in the gut microbiota have been linked to GLP-1RAs 26,27,28
