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FEMS Microbiol Ecol 73:3142

The results showed that patients with recurrent ovarian cancer had elevated p53-SLP immunogenicity after low doses of cyclophosphamide were administered

Loss of tumor suppressor phosphatase and tensin homolog (PTEN) leads to activation of PI3K signaling, which is associated with increased anti-inflammatory cytokines, such as VEGF and CC motif chemokine ligand 2 (CCL2), reduced infiltration of CD8+ T cells into tumors, and decreased IFN- expression, conferring resistance of PD-1 blockade therapy against tumors (56)

Hsieh MJ, Lee CH, Chueh HY, et al

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