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AOD-9604 was designed to specifically target fat metabolism pathways without many of the broader hormonal effects associated with HGH

Rather than morning administration competing with the growth hormone peak stimulated by secretagogues (often administered at night), AOD-9604 moves to morning while CJC-1295/Ipamorelin administers before bed

Growth hormone peptides synergize with optimized testosterone but may require insulin monitoring if testosterone is also increasing insulin sensitivity

This avoids the famous, but famously unavailable, Schilling test

This paper established NNMT as a legitimate research target for adipose biology specifically and triggered the broader small-molecule NNMT inhibitor research that includes 5-Amino-1MQ