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For weight management , NICE technology appraisals TA875 (semaglutide 2.4mg, Wegovy) and TA664 (liraglutide 3.0mg, Saxenda) specify different continuation criteria and require specialist service involvement

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Liraglutide (LEADER trial), semaglutide (SUSTAIN-6), and dulaglutide (REWIND trial) demonstrated significant reductions in major adverse cardiovascular events, while others showed cardiovascular safety without superiority

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Patients who eat less may experience nutrient deficiencies, which increases the risk of hair loss