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The way in which GLP-1 drugs are causing weight loss is without question due to suppression of food intaketo satiety, Hayes adds

This builds on his work to understand 'how circulating GLP-1 can produce multiple actions, both directly and indirectly, on multiple organs' which he has pursued for many years with colleagues (McLean, Wong, Campbell)

However, cardiovascular safety trials in type 2 diabetes patients, the majority presenting cardiovascular disease and excess weight, showed that GLP-1 receptor agonists were indeed capable of decreasing cardiovascular risk

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