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For example, in the ADJUNCT ONE trial, the rate of nausea with the highest dose of liraglutide (1.8mg) was 49.6% compared to 12.1% in the placebo

Margulies KB, Hernandez AF, Redfield MM et al (2016) Effects of liraglutide on clinical stability among patients with advanced heart failure and reduced ejection fraction: a randomized clinical trial

Supporting Study: Smith, R

The enzymes that constitute the de novo thymidylate pathway include cytosolic serinehydroxymethyl transferase (cSHMT), thymidylate synthase (TYMS) and dihydrofolate reductase (DHFR)