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These results are consistent with previous studies, which reported no significant changes in cell growth or morphology in ARPE-19 cells exposed to a final concentration of 30 mM glucose [23]
Level of evidence Level IV, therapeutic case series
It is not practical for everyone and might take a while to work
Metformin alleviates glucolipotoxicity-induced pancreatic cell ferroptosis through regulation of the GPX4/ACSL4 axis
Patients losing more than 1.5% of body weight per week show the most significant elevations in lipid peroxidation and are the population most likely to benefit from antioxidant support
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