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DJ-1 binds to subunits of mitochondrial complex I and regulates its activity (Hayashi et al., 2009)
Complex I deficiencies of the respiratory chain account for the majority of unfavorable neuronal degeneration in PD
Metformin treatment with concentrations of 10, 25, and 50 M significantly restored chondrocyte viability suppressed by H 2 O 2 exposure, and 50 M metformin was chosen for further studies (Fig
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