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During the treatment, no significant change in the body weight of the mice was observed, indicating that NP4 has a high biocompatibility (Supplementary Fig
Furthermore, there is an increase in procoagulant proteins (thrombomodulin, von Willebrand factor) and a decrease in anticoagulant proteins (protein C, antithrombin) favoring hypercoagulability and immunothrombosis [80, 81]
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