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While useful as a simplified framework that characterizes microglia as either pro-inflammatory (M1) or protective/repair-oriented (M2), the classical M1/M2 dichotomy does not fully capture the diverse and dynamic activation states of microglia, which often exist along a phenotypic continuum between pro-inflammatory and protective functions (Tastan and Heneka, 2024

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Then we did some more experiments in other clinically relevant mouse models, finding and treating cancer that had metastasized to the liver as well as primary tumors, which shows the potential for broad application of this approach. Next, the researchers are working to improve the selectivity and detection capabilities even further so that they can detect micro-metastases, or tiny clusters where the cancer has spread, anywhere in the body

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