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Whilst highly effective, these medications can cause gastrointestinal side effects including nausea, vomiting, and diarrhoea, potentially leading to fluid and electrolyte losses
There have also been concerns about pancreatic cancer, mostly because of early reports of pancreatitis: inflammation of the pancreas, which can, in some cases, be fatal
GLP-1 RA use was consistently associated with improvements in headache frequency, weight reduction, and reduced need for acetazolamide or surgical interventions
Understanding these predispositions does not predict your exact response to semaglutide, but it may help contextualize whether GLP-1 therapy fits your genetic and metabolic landscape
This means running them together should not dramatically increase the burden of side effects compared to running either one alone
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