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It upregulates the expression of vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), and their respective receptors at sites of injury, directly promoting angiogenesis and epithelial repair

In addition, some sHSPs, such as HSPB1/HSP27 and HSPB5, can be phosphorylated through kinase pathways, including the p38/MK2 pathway, which may regulate their chaperone activity, cytoskeletal interactions, and involvement in autophagy-related clearance of damaged cellular components (Ungelenk et al., 2016

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Regulation of Muscle Mass by Growth Hormone and IGF-1. British Journal of Pharmacology.

The reversed sequence combined with D-amino acids produces a mirror-image topology that is functionally equivalent to the native FOXO4 binding domain for protein-protein interaction disruption, a design strategy validated in the landmark 2017 Cell study