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Molecular analyses showed that CO23RFLC had acquired a marked increased expression of the MDR1 gene encoding for an efflux pump protein mainly responsible for the drug-resistance, due to a mutation in the transcription factor gene MRR1 [16] whereas CO23RFK had a homozygous mutation (S645Y substitution) in the FSK1 gene, responsible for the synthesis of glucan [17]
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"Tirzepatide versus semaglutide once weekly in patients with type 2 diabetes." New England Journal of Medicine , 385(6), 503-515
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