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236 Upon ligand binding, TGF- receptor II (TRII) recruits and phosphorylates TRI, which activates Smad2/3

55 In esophageal squamous cell carcinoma (ESCC), QSOX2 promotes disulfide bond formation in TSC2, enhancing its phosphorylation by Akt and activating the mTOR/4E-BP1/c-Myc axis, thereby upregulating CSC markers (e.g., CD44, Notch1) and promoting platinum resistance

(More information) Some evidence from small randomized controlled studies suggests that high-dose lipoic acid may improve measures of glucose utilization in subjects with metabolic disorders

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