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The different additives added to the liposomes for efficient drug delivery including ethanol, penetration enhancers and edge activators also modify the characteristics of the lipid bilayer [357]

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2.2.1.2 Quercetin, kaempferol, isobavachalcone and gambogic acid Quercetin and kaempferol, which are natural flavonoids, when used in combination with Smac mimetics, induce the proteasomal degradation of cellular inhibitor of apoptosis proteins one and 2 (cIAP1/2) and synergistically kill cholangiocarcinoma cells through RIPK1/RIPK3/MLKL-mediated necroptosis (Lomphithak et al., 2023)