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A review study proposed another mechanisms underlying the potential interaction of the smoking and oestrogen metabolites such as decrease in oestrogen activity, SHBG levels, aromatase enzyme activity, C-20, 22 desmolase enzyme levels and increase in free testosterone levels, hyperandrogenism and the hepatic metabolism of steroid (Reference Ruan and Mueck41)

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Sources Food sources Cruciferous vegetables Cruciferous vegetables, such as bok choi, broccoli, Brussels sprouts, cabbage, cauliflower, horseradish, kale, kohlrabi, mustard, radish, rutabaga, turnip, and watercress, are rich sources of glucosinolate precursors of isothiocyanates (63)

Why this matters: Higher doses slow digestion more aggressively Sudden appetite suppression can shock your system Increases risk of nausea, fatigue, and dizziness What to do: Follow a gradual dosage plan Stay at each dose level until your body adapts Never increase dose just to speed up weight loss Key Insight: Slower progression = fewer side effects + better long-term results 2

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