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First, acute and chronic EtOH administration induce overproduction of ROS, RNS and other free radicals, observations made in cell cultures, experimental animals and human subjects

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In addition, SQSTM1 can recognize ubiquitinated Parkin, a key protein of mitophagy, and disrupted SQSTM1 mediates mitophagy deficiency (Song et al., 2016), which is an important cause of PD

It presents the mechanism as shared across the class rather than unique to any single product