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B12 books I found useful "What You Need to Know About Pernicious Anaemia and B12 Deficiency" by Martyn Hooper Martyn Hooper is the chair of PAS (Pernicious Anaemia Society)

Notes that high-dose niacin passes into breast milk and that lipid-altering doses could pose risks to nursing infants, recommending caution or avoidance of such doses during breastfeeding)

Optimized volume/price ratio, extended autonomy (several weeks at typical 250-500 mcg dose), final concentration adjustable to protocol (5 mg/ml with 2 ml bacteriostatic, or 2.5 mg/ml with 4 ml for finer dosing)

Often blended for convenient research use

The documented pattern is simply a steady daily presence of the inhibitor, held long enough for the downstream metabolic change to accumulate