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Our results showed that while Nrf2 deficiency did not trigger spontaneous tinnitus, it increased the mices susceptibility to noise-induced tinnitus and worsened neuroinflammation
6100 to Rs
93 , 901s905s (2011)
Schisandra chinensis lignans suppressed the phosphorylation of key signaling molecules, including IB kinase alpha/beta (IKK/), inhibitor of nuclear factor kappa-B alpha (IB), protein kinase B (Akt), TANK-binding kinase 1 (TBK1), ERK, p38, JNK, NF-B (p65), c-Jun, and interferon regulatory factor 3 (IRF3), thereby disrupting the IKK//NF-B, MAPK/AP-1 (c-Jun) and TBK1/IRF3 pathways, which play pivotal roles in inflammation [32]
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