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Patients should be advised to: Start with the lowest dose and increase slowly Eat smaller, more frequent meals Avoid high-fat foods Stay well-hydrated Safety monitoring should include vigilance for: Pancreatitis symptoms (severe persistent abdominal pain) discontinue immediately if suspected Gallbladder disease increased risk with rapid weight loss Hypoglycaemia particularly when combined with insulin or sulphonylureas Renal function deterioration especially with dehydration from gastrointestinal effects Diabetic retinopathy monitor in patients with pre-existing retinopathy, particularly with semaglutide Suspected adverse reactions should be reported via the MHRA Yellow Card scheme

and vomiting (RR = 4.16

12 Prescriptions Per Year: A single patient on a full-year regimen would require 12 prescriptions annually

doi: 10.1016/j.diabres.2018.03.020 82 TienNWuTYLinCLChuFYWangCCNHsuCYet al

10.1200/JCO.20.03565 49 MercerJ.LeeJ