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The gradual dose escalation protocol recommended for Saxendastarting at 0.6 mg daily and increasing weekly by 0.6 mg increments to the maintenance dose of 3.0 mgis specifically designed to improve gastrointestinal tolerability, as per the UK SmPC
So what's the big deal
Ongoing research continues to evaluate the long-term cardiovascular impact of GLP-1 receptor agonists
Well-powered, controlled trials are needed to confirm efficacy and safety, identify optimal subgroups, and evaluate long-term outcomes
You may experience one or more of these side effects: Nausea Vomiting Diarrhea Constipation Stomach pain Indigestion These effects are most common during the early dose-escalation phase and tend to lessen as the body adjusts
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