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Zhang et al., 2018), withaferin A (Choi and Kim, 2015

By inhibiting glucagon secretion, GLP-1 ensures that less glucose is released into the bloodstream, further helping to maintain stable blood sugar levels

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| Parameter | Saxenda (Liraglutide 3 mg) | Retatrutide (Phase 2, 12 mg) | |-----------|--------------------------|------------------------------| | Titration duration | 5 weeks | ~24 weeks | | Dosing frequency | Daily | Weekly | | Mean weight loss | 8.0% at 56 weeks | 24.2% at 48 weeks | | Nausea (any grade) | 39.3% | 45% | | Vomiting (any grade) | 15.7% | 25% | | Diarrhea (any grade) | 20.9% | 22% | | GI-related discontinuation | ~9.8% | ~6% | | Heart-rate increase (mean) | ~2 to 3 bpm | ~4 bpm | | FDA approval status | Approved (2014) | Not yet approved | | Injection frequency | Daily | Weekly | Sources: SCALE 2015 [14], Jastreboff 2023 [15]