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In mice single-cell RNA sequencing identified a subpopulation of GLP-1R-positive memory T-cells that was mainly composed of exhausted CD8+ T cells: functionally, stimulation of the GLP-1R on these cells was found to mediate apoptosis and anergic signals, thereby suppressing effector T-cell function and the inflammatory response ( 3.2 Intestinal mucosal barrier IELs are a heterogeneous population of T cells located among intestinal epithelial cells (IECs), where they contribute to maintaining mucosal barrier integrity ( Glp1r / mice displayed greater levels of epithelial damage in comparison to wild-type (WT) mice following inflammatory stimulation
In addition to its diabetes benefits, Ozempic is now FDA-approved to: Lower blood sugar in adults with type 2 diabetes
January 2022, 27 (1): 324
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