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The best way to get enough vitamin B12 is through a healthy diet whenever possible, such as from consuming grass-fed beef, poultry or wild-caught fish
Additionally, certain long-term medicationssuch as antacids or metformincan interfere with B12 absorption
Because it competes at the nicotinamide substrate site rather than the SAM cofactor site, it is also used as the substrate-competitive reference compound against which bisubstrate and covalent NNMT inhibitors are benchmarked
Energy levels and mental clarity often improve first
Microdosing is a drug administration method involving significantly lower doses than are typically used for therapeutic effects
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