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Neither is approved by the FDA as a medicine, dietary supplement, or health product, meaning they cannot legally be sold for human consumption or therapeutic use outside of an approved clinical trial context

However, this conceptual framework remains hypothesis-generating and underscores the need for further mechanistic and clinical studies to clarify causality and tissue-specific effects

316 In KRAS/LKB1-mutant NSCLC, resistance to KRAS inhibitors such as adagrasib involves adeno-to-squamous transdifferentiation (AST), driven by Np63 and characterized by KRT6A expression

Furthermore, the expansion of the targeted treatments into broader health concerns, such as reducing the risk of dementia, has broadened their appeal

For any athlete subject to anti-doping rules, TB-500 is a prohibited substance