Figure 1 In line with these observations, weight loss has emerged not only as a supportive strategy but also as a disease-modifying intervention in PsA ( Preclinical studies further suggest that GLP-1RAs may modulate key cytokine pathways implicated in psoriatic disease, including NF-B, IL-6, IL17, and IL23, while small clinical studies have reported improvements in skin disease severity in PsO ( This narrative review summarizes the current clinical evidence on GLP-1RAs in PsO and PsA and discusses future research directions aimed at evaluating their potential role in intercepting PsA development and improving outcomes in patients with complex immunometabolic profiles
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4.2 SGLT2 inhibitors in the central nervous system SGLT1 is localized in the pyramidal cells of the brain cortex, Purkinje cerebellum cells, hippocampus pyramidal, and granular cells (Pawlos et al., 2021)
