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weight-loss pharmacotherapy may not be appropriate Gastrointestinal conditions, particularly gastroparesis or inflammatory bowel disease Thyroid disorders (report any symptoms such as neck swelling, difficulty swallowing, or hoarseness) Diabetes and current glycaemic control Cardiovascular conditions Any history of pancreatitis or gallbladder disease All current medications and supplements must be disclosed, as both Wegovy and escitalopram may interact with other medicines

Treatment of SAD is started in the fall before depressive symptoms begin and continued throughout the winter until early spring

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Additionally, tirzepatide demonstrates bias at the GLP1R, favoring the synthesis of cAMP over the recruitment of -arrestin [1]

Researchers should also stratify patients by baseline neuropathy severity and diabetes duration