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We may be living longer, but those extra years often come with poor health, more prescriptions, and a slow decline in quality of life

Additional differential enrichment analysis found that proteins related to the mitophagy pathway, such as Sqstm1, Bnip3, Map1lc3b, and Optn, were significantly upregulated, suggesting an increase in mitochondrial damage

But some men plateau

Table 2 illustrates how the microbiome may be effected by long-term PPI use

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