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Sodium-Glucose Transport 2 (SGLT2) Inhibitors
Further, biomarker concentrations are tricky to interpret: Total GSH concentration often fails to accurately reflect redox balance, which is better indicated by the GSH to GSSG ratio, plasma/serum concentrations are often a weak correlate of tissue level (the locus of action), and compartmentalization within cells (cytosol versus mitochondria) adds another layer of complexity often out of grasp in clinical samples [31]
In contrast to conventional CuNC-based probes that often depend on toxic or synthetic ligands, this approach utilizes BSA as both a reducing and stabilizing agent
PMID: 25995620
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