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In a head-to-head REDEFINE 4 trial, CagriSema achieved 23% average weight loss over 84 weeks, falling short of Eli Lillys tirzepatide (the molecule behind Mounjaro/Zepbound) at 25.5 % and missing the studys primary goal of non-inferiority

So, if you cant get 100 grams of protein in a day, and for many people listening, theyre like, Oh, my gosh, Im probably getting 50 or 60, thats the first thing to work up to

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FDA approval in 2026 is considered unlikely (prediction markets put it at ~27%)

Electrolyte imbalances cause muscle cramps, dry mouth , fatigue, and heart palpitations