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Nat Rev Dis Primers 12 , 5 (2026)

Research-use-only means the compound is sold strictly for laboratory or analytical research and is not approved for human or veterinary use

These indicators (Moreno et al., 2019) include cellular or serum markers such as total cholesterol (TC), glutamic oxaloacetic transaminase (AST)

Moreover, inhibition of system xCT could lower the activity of GPX4, the vital antioxidant enzyme which allowed for blocking ferroptosis through reducing lipid hydroperoxides (Liu et al., 2017)

Use in active lifestyles remains investigational because BPC-157 lacks regulatory approval for clinical application in many regions, and current evidence is largely limited to laboratory and animal studies rather than confirmed human outcomes