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We propose that the effects of cumulative loss of surface receptor with fast-internalizing, slow-recycling, lysosome-targeting agonists, along with increases in -arrestin-induced desensitization, become more apparent with time, eventually overriding any positive effects associated with noncanonical signaling

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The list of species and NCBI accession numbers, as well as the corresponding peptide sequences, are provided in Supplementary Tables 15 and 16

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Drinking a lot of water flushes out toxins from the body and hydration would also lessen the swelling around the injection area