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In response to growth signals, mTORC1 activates ATF4, which stimulates the expression of core enzymes in serine synthesis and the folate cycle for de novo purine synthesis required for DNA replication and ribosome biogenesis in rapidly growing and proliferating tumor cells (Denicola et al., 2015
The modification was developed to help enhance the half-life of the protein and allow it to obstruct the normal FOXO4 function
Supports energy production and faster recovery
Dos Santos MCF et al
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