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Berberine does interact with GLP-1 pathways in human intestinal L-cells through multiple mechanisms, but the magnitude of GLP-1 activation in humans taking this supplement has not been quantified in published research

Not a dealbreaker, but a step behind #1-3 on this list

Dutogliptin, a selective DPP4 inhibitor, improves glycaemic control in patients with type 2 diabetes: a 12-week, double-blind, randomized, placebo-controlled, multicentre trial

Available treatments: GLP-1 weight loss treatment Bloodwork for weight loss These injections support energy, fat metabolism, and appetite control under clinical supervision

PMCID: PMC8166598.