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For patients with chronic kidney disease, heart failure, or established atherosclerotic cardiovascular disease, substituting a sodium-glucose cotransporter 2 (SGLT2) inhibitor may be preferred

Higher doses slow gastric emptying more aggressively, which means more constipation

[28] [29] Patients should maintain open communication with their healthcare team, report new symptoms promptly, and never discontinue prescribed medications without medical guidance

However, the efficacy of oral glutathione supplements is being questioned due to concerns about poor absorption in the gastrointestinal tract

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