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Generally safe, but medical clearance is required before treatment
ACK1 further phosphorylates AR at Y267, sustaining the oncogenic activity of acK609-AR and promoting the growth of castration-resistant prostate cancer (CRPC)
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Enhanced expression of GSH metabolism enzymes including glutathione peroxidases, gamma-glutamyl cysteinyl synthetase (gamma-GCS), glutathione S-transferases (GST), and ABC-family membrane transport proteins including the multidrug resistance-associated protein (MRP) were all documented to play prominent roles in cellular resistance to oxidative stress
