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Since mitochondria are one of the crucial organelles involved in the manifestation of radiation-induced apoptosis, Stoyanovsky and coworkers anticipated that mitochondrial targeting of ebselen may further improve its radioprotective activity by detoxifying the mitochondrial overproduction of hydroperoxide (H 2 O 2 ) and the accumulation of lipid hydroperoxides
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Patients with existing cardiovascular disease actually experienced cardiovascular benefits (reduced heart attacks and strokes) despite temporary heart rate elevation, suggesting the overall metabolic effects of weight loss outweigh concerns about transient rate changes
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