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Although there are no standard criteria for the clinical and biomarker evidence required to support disease modification, clinical measures such as a change in trajectory of decline, an increasing drug versus placebo difference over time, an increased time to event, and an enduring change after discontinuation support this terminology
The thyroid gland plays a crucial role in regulating metabolism, energy production, body temperature, and numerous other physiological processes
A propensity-matching approach might have yielded more balanced study groups and increased the internal validity of the findings
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