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This triple-agonist mechanism is what makes it potentially more effective than single-agonist peptides like semaglutide , but it also means the gastrointestinal side effects can be more intense if you start too high
doi: 10.22358/jafs/73884/2004 50 GrauletB.RichardC.RobertJ
They slow gastric emptying , prolonging the sensation of fullness after meals, and act on appetite centres in the brain to reduce hunger and food intake
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