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John D Hayes, Jack U Flanagan, Ian R Jowsey 2005
Injections bypass those issues
Choosing the right medication depends on your specific health needs and goals
Hence, one potential explanation for the increased efficacy of tirzepatide on glycemic control relative to the monoagonist GLP-1RA is that targeting both incretin receptors maintains some insulinotropic activity even in subjects who are relatively insensitive to GLP-1
Genetic variations in GLP-1 receptor sensitivity, MC4R signaling, and metabolic pathways may partially explain individual differences in appetite regulation and glucose control, making personalization increasingly relevant to treatment planning
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