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While singly-housed animals may experience stress that impacts metabolism, body weight, and adiposity 65,66,67,68,69 , the singly-housed animals in this study were treated identically (to the best of the experimenters ability) to minimize and equalize stress across all animals and reduce confounding variables

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1 2 European Journal of Organic Chemistry

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Some have FDA approval for very specific conditions (e.g., tesamorelin for HIV-related lipodystrophy), but using them outside of that is considered off-label